Inter Milan vs AC Milan - Serie A Week 12 Preview - 11/23/2025

This weekend, the San Siro hosts the classic Derby della Madonnina skirmish between two of the top teams in Serie A, AC and Inter Milan.

Serie A is back once again with 1st place in the league up for grabs between 5 separate teams. Inter Milan have been highly complacent so far as they lead the UEFA Champions League with 4 straight wins, and continue a 3 game win streak in the Serie A. AC Milan have a lot to prove if they want to usurp their Inter rivals and continue their hopes of finishing 1st place in the league.

Inter Milan haven't lost a match since September 13 in a 4-3 result against Juventus, as I Nerazzurri currently reside at 2nd place with 24-points and an 8-0-3 record, as Napoli took 1st with their 3-1 win over Atalanta this weekend. Inter Milan's last match ended in a crucial 2-0 victory over Lazio, with Lautaro Martinez striking early in the 3', followed up by Ange-Yoan Bonny in the 62'.

Hakan Calhanoglu comes in as Inter's most potent scorer with 5 goals so far this season (+400 anytime this match). Martinez has 2 goals in his last 2 games and comes in marked to score anytime at +137 odds, with Ange Bonny the most likely goal scorer of the afternoon at +120.

AC Milan will be vicious contenders, having knocked out Inter of the Coppa Italia Semifinals 4-1 on aggregate last April. This season, I Rossoneri look to climb ahead from 5th place in the league with 22 points and a 6-4-1 record, after drawing 3 of their last 5 domestic matches. In their most recent game on November 8 before the break, Milan struck an early 2-0 lead over Parma with a 12' finish from Alexis Saelemaekers, before Rafael Leao tucked away a 25' penalty. Parma's Adrian Bernabe pulled a goal back in the 45+1' just before the half, only for Enrico Del Prato to equalize in the 62' for a 2-2 draw.

Milan's Cristian Pulisic is finally expected to return after suffering a longtime hamstring injury. Both he and Rafael Leao have 4 goals each in 7 games played, with either (or both) expected to net one tomorrow afternoon anytime at +300 odds. Santiago Gimenez, enters the fold as AC's highest probable player to hit the back of the net at +175 odds.

Both teams are in their home element, although Inter takes a -106 odd advantage due to the teams incredible consistency in all competitions this season. Milan aren't out for the count though, as they come in as slight +280 underdogs, with a draw set at +240. Both the over and under 2.5 are priced at -110, with 2 of AC's last 3 games ending with under 2.5 total goals, and 2 of Inter's last 3 games ending at over 2.5 total goals, so expect both sides to cherish their chances tomorrow.

Get amped for one of the biggest rivalries of the season, with the Derby della Madonnina between Inter and AC Milan kicking off at 2:45 pm EST. Find the projected lineups for the game below.

Who will win?

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  Inter Milan (-106)
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  Draw (+240)
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  AC Milan (+280)